C60 Cancer Research

Using water-soluble C60 fullerenes in anticancer therapy (2011)

"C60 fullerenes efficiently inhibit the growth of transplanted malignant tumors."

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Photodynamic therapy with fullerenes in vivo (2011)

"Glycoconjugated-C60 compounds produced selective phototoxicity toward cancer cells compared with normal fibroblasts."

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C60 fullerene as a synergistic agent with doxorubicin (2014)

"C60 fullerene has… antitumor potential and may be useful in modulating cell responses to Dox."

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C60 + LED photodynamic killing of leukemic cells (2018)

"C60 fullerene… induced apoptosis of leukemic cells after photoexcitation with a 405-nm LED."

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C60 and nanocomplexes with anticancer drugs (2018)

"C60 fullerene used alone or conjugated with chemotherapeutic agents possesses a potent anticancer activity."

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C60 sonodynamic treatment of cancer cells (2023)

"C60’s ability to induce apoptosis of carcinoma cells after sonoexcitation with ultrasound provides a promising approach for cancer treatment."

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C60-polymer nanoparticles for PDT (A549, 2023)

"C60-polymer nanoparticles showed strong photodynamic therapy effects on human lung cancer cells."

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C60 nano-photosensitizer for colorectal cancer (2024)

"C60 photosensitized drug promoted tumor killing… with no significant toxic effects on normal cells."

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Non-melanoma skin cancer PDT using [60]fullerene nanomaterials (2020)

"[60]Fullerene-enabled topical PDT was effective against non-melanoma skin cancer models."

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Fullerene derivatives for tumor treatment: mechanisms & application (2024 review)

"Photodynamic killing of tumor cells by fullerenes involves mitochondria-induced apoptosis and membrane-disruption-induced cell death."

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Fullerenes for the treatment of cancer: an emerging tool (2022 review)

"C60(OH)20 showed inhibition of tumor cell proliferation in the EMT-6 breast cancer metastasis model."

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Applications of functionalized fullerenes in tumor theranostics (2012 review)

"Functionalized fullerenes have been applied to photoacoustic imaging… and show potential in tumor therapies."

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Synergy of chemo- and photodynamic therapies with C60-Dox nanoformulation (2019)

"A combination of chemo- and photodynamic therapies with C60-Dox provides a promising synergistic approach for cancer treatment."

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Influence of C60 nanofilm on gene expression in liver cancer cells (2023)

"C60 nanofilm downregulated TGF and reduced key invasion markers (MMP-1, MMP-9, TIMP-1/2/4)…"

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Application of fullerene derivatives in medicine… (HepG2, C3A lines)

"Fullerene exhibited cytotoxicity on cancer cell lines… nanofilm altered the behavior of cancer cells toward normalcy."

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Medicinal applications of fullerenes (2007 overview)

"The C60 core can penetrate hydrophobic binding sites… (modeling suggests a drug-relevant interaction)."

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Photostimulated spin-flip & photodynamic effect of fullerene solutions (2010 theory)

"Spin flip of electrons in molecular oxygen near fullerene ions underlies high oxidative activity of C60–O2 complexes."

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C60 fullerene sonodynamic treatment (MDPI, 2023)

"C60’s ability to induce apoptosis after sonoexcitation provides a promising novel approach for cancer treatment."

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